ITT Cancer Research – Apoptosis – Oncology

MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)

MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Liver cancer is of the devastating human cancers and its incidence is increasing at an alarming rate. The clinical outcomes are far from descent due to lack of efficient therapeutic targets and chemotherapeutic agents. Studies have revealed the therapeutic implications of microRNAs in the management of different human cancers. This study was designed to explore the role and therapeutic potential of miR-638 in liver cancer via modulation of zeste homolog 2 (EZH2). The results revealed significant (P < 0.05) downregulation of miR-638 in human liver cancer tissues and cell lines.

Overexpression of miR-638 led to a significant (P < 0.05) decline in liver cancer cell proliferation. Nonetheless, inhibition of miR-638 could promote the proliferation of the human liver cancer cells. The DAPI and annexin V/PI staining assays revealed that miR-638 induces apoptosis in human liver cancer cells which was accompanied by enhancement of Bax and depletion of Bcl-2 expression. Furthermore, miR-638 overexpression also leads to a significant (P < 0.05) increase of autophagosomes and autolysosomes in liver cancer cells suggestive of autophagy. The induction of autophagy was further confirmed by increase and decrease in expression of LC3B-II and Beclin-1 proteins, respectively. In contrary, inhibition of miR-638 prevented both apoptosis and autophagy of the liver cancer cells. In silico analysis and the dual luciferase assay revealed EZH2 as the molecular target of miR-638 at post-transcriptional level. The qRT-PCR showed that EZH2 to be significantly (P < 0.05) upregulated in the human liver cancer tissues and cell lines.

However, the expression of EZH2 was considerably suppressed upon miR-638 overexpression in SNU-423 cells. Taken together, these findings suggest the tumor-suppressive role of miR-638/EZH2 axis liver cancer and point towards the potential of miR-638 as therapeutic target in the treatment of liver cancer. WST-1 assay was used to determine cell viability. The fact that ambrosin induced apoptosis was studied through acridine orange (AO)/ethidium bromide (EB) staining using fluorescence microscopy as well as using flow cytometry in association with annexin-v/propidium iodide (PI) staining. Furthermore, western blot assay was used to study effects of ambrosin on apoptosis-related protein expressions including Bax and Bcl-2, as well as to study the effects on numerous caspases and Akt/β-Catenin Signaling Pathway. The effects on reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were evaluated by flow cytometry.

A Logic AND-Gated Sonogene Nanosystem for Precisely Regulating the Apoptosis of Tumor Cells

To date, many methods have been developed for inducing tumor cell death, such as using chemical drugs and radiation. However, all of them have a common problem, a lack of mechanisms for precisely regulating the death of tumor cells. It often leads to nonspecific death and systemic side effects. Therefore, the efficacy and further application of these traditional methods are limited. In this paper, a logic AND-gated sonogene nanosystem was designed for precisely regulating the apoptosis of tumor cells. The running of this system required two essential parts, MscL I92L channel protein and ultrasound. Ultrasound could open the MscL I92L protein channel which when expressed on cells triggers the influx and outflux of small molecules through the channel. When the channel is kept open for a long time, Ca2+ influx becomes excessive which in turn activates the Ca2+ apoptosis pathway of cells.
The expression of MscL I92L protein and the applying of ultrasound constituted the logic AND gate which could implement the precise regulation to apoptosis. This strategy would help reduce nonspecific triggers and side effects. In this system, cationic nanoliposomes were prepared as the carrier for effectively delivering MscL I92L plasmids to tumor cells in vivo. We investigated the apoptosis-promoting effect of this system in different tumor cell lines (HeLa, B16, and 4T1). The results demonstrated that the apoptosis rate was highest in the B16 cell line (the early apoptosis rate was 11.9% and the late apoptosis rate was 59.1%) when the cells were subjected to consistent ultrasound (6 MHz, 15 W) for 30 min. This logic AND-gated sonogene nanosystem is expected to provide a new strategy and development direction for tumor therapy.
 MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)
MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)

Anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunostimulation in the host and decreases blood toxic effects of taxol in an animal model

Many antineoplastic agents induce myelosuppression and leukopenia as secondary effects in patients. The development of anticancer agents that simultaneously provoke antitumor immune response represents an important therapeutic advance. The administration of 6-pentadecyl salicylic acid (6SA) contributes to the antitumor immunity using 4 T1 breast cancer cells in Balb/c female mice, with Taxol as a positive control and in cotreatment with 6SA (6SA + Taxol; CoT). Our results show that 6SA reduces tumor volume and size by inducing caspase-8-mediated apoptosis without reducing tumor infiltrated lymphocytes. Also, 6SA reduced lung metastasis and increased the proportion of immune cells in blood, lymph nodes and bone marrow; more evidently, in the proportion of tumor-infiltrated natural killer (NK) cells and cytotoxic T lymphocytes.

Goat Anti-Mouse Lambda antibody (AU)

STJ99354-1mL 1 mL
EUR 999
Description: AU conjugated Goat polyclonal to Mouse Lambda

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EUR 179
Description: Biotin conjugated Goat polyclonal to Mouse Lambda

Goat Anti-Mouse Lambda antibody (Biotin)

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EUR 999
Description: Biotin conjugated Goat polyclonal to Mouse Lambda

Goat Anti-Mouse Lambda antibody (FITC)

STJ99454-100l 100 µl
EUR 179
Description: FITC conjugated Goat polyclonal to Mouse Lambda

Goat Anti-Mouse Lambda antibody (FITC)

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EUR 999
Description: FITC conjugated Goat polyclonal to Mouse Lambda

Goat Anti-Mouse Lambda antibody (HRP)

STJ99504-100l 100 µl
EUR 179
Description: HRP conjugated Goat polyclonal to Mouse Lambda

Goat Anti-Mouse Lambda antibody (HRP)

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EUR 999
Description: HRP conjugated Goat polyclonal to Mouse Lambda

Goat anti Human Lambda Chain (rhodamine)

43C-CB9130 1 mg
EUR 361
Description: Goat anti Human Lambda Chain secondary antibody (Rhodamine)

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43C-CB9132 1 mg
EUR 361
Description: Goat anti Human Lambda Chain secondary antibody (biotin)

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43C-CB9133 1 mg
EUR 396
Description: Goat anti Human Lambda Chain secondary antibody (HRP)

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EUR 246
Description: Goat polyclonal anti Human Lambda light chain antibody

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EUR 192
Description: Goat polyclonal anti Human Lambda light chain antibody

Goat anti Human Lambda light chain

20-S2601G000-V0 10 ml
EUR 133
Description: Goat polyclonal anti Human lambda light chain antibody

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20-S2601G000-VO 10 ml
EUR 149
Description: Goat polyclonal anti Human Lambda light chain antibody

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EUR 165
Description: Goat polyclonal anti Human Lambda light chain antibody

Goat anti Human Lambda Chain (FITC)

60C-CB9129 1 mg
EUR 361
Description: Goat anti Human Lambda Chain secondary antibody (FITC)

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

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EUR 280

Polyclonal Goat anti-GST p-form

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EUR 280

Goat Anti-Mouse Lambda-HRP

LF-SA8067H Ask for price
Description: Goat polyclonal to Mouse Lamda

Goat Anti Human Lambda Light Chain Polyclonal Antibody

CPBT-65590GH 1 mg
EUR 580

Goat Anti Human Lambda Light Chain Polyclonal Antibody

CPBT-65597GH 1 ml
EUR 429

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Goat anti Human Lambda Chain (Texas Red)

43C-CB9131 1 mg
EUR 361
Description: Goat anti Human Lambda Chain secondary antibody

Goat anti Human Lambda Chain (Alk Phos)

43C-CB9134 1 mg
EUR 417
Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos)

Goat anti Human Lambda Chain (Fab'2)

41C-CJ0134 1 mg
EUR 405
Description: Goat anti Human Lambda Chain secondary antibody (Fab'2)

Goat anti Human Kappa + Lambda light chain

20-S1701G000-V0 10 ml
EUR 138
Description: Goat anti Human kappa + lambda light chain secondary antibody

HRP*Polyclonal Goat Anti-Mouse Lambda

C030215-101ml 10.1ml
EUR 227

HRP*Polyclonal Goat Anti-Mouse Lambda

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EUR 945

FITC*Polyclonal Goat Anti-Mouse Lambda

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EUR 227

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Anti-Lambda antibody

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EUR 493

Anti-Lambda antibody

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EUR 212

Goat Anti Human Lambda Light Chain Polyclonal Antibody,FITC

CPBT-65588GH 1 mg
EUR 580

Goat Anti Human Lambda Light Chain Polyclonal Antibody,HRP

CPBT-65589GH 1 ml
EUR 580

Goat anti Human Lambda Chain (Fab'2) (FITC)

43C-CJ0135 1 mg
EUR 395
Description: Goat anti Human Lambda Chain secondary antibody (Fab'2) (FITC)

Goat anti Human Lambda Chain (Fab'2) (HRP)

43C-CJ0137 1 mg
EUR 417
Description: Goat anti Human Lambda Chain secondary antibody (Fab'2) (HRP)

Goat anti Mouse Lambda Light Chain (HRP)

60R-LG002hrp 1 mg
EUR 457
Description: Goat anti Mouse Lambda Light Chain secondary antibody (HRP)

Goat Anti Human Lambda Light Chain (Mouse Adsorbed) Polyclonal Antibody

DPBT-65595GH 1 mg
EUR 715

Lambda, Light Chains; Polyclonal (Ready-To-Use)

A00065-0002 2 ml
EUR 79

Lambda, Light Chains; Polyclonal (Ready-To-Use)

A00065-0007 7 ml
EUR 108

Lambda, Light Chains; Polyclonal (Ready-To-Use)

A00065-0025 25 ml
EUR 252

Lambda DNA/HindIII Marker, Ready-to-use

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  • Product category: Electrophoresis Related/Ladders - DNA/Lambda DNA/HindIII

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  • Product category: Electrophoresis Related/Ladders - DNA/Lambda DNA/HindIII

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  • Product category: Electrophoresis Related/Ladders - DNA/Lambda DNA/HindIII

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  • Product category: Electrophoresis Related/Ladders - DNA/Lambda DNA/HindIII

Anti-Lambda 5 Antibody

A08965 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Lambda 5 Antibody (IGLL1) detection.tested for IHC, WB in Human.

Anti-Lambda 5 antibody

STJ93884 200 µl
EUR 197
Description: Rabbit polyclonal to Lambda 5.

Anti-Lambda 5 antibody

STJ97336 200 µl
EUR 197
Description: Rabbit polyclonal to Lambda 5.

Goat anti Human Lambda Chain (Fab'2) (Texas Red)

43C-CJ0136 1 mg
EUR 385
Description: Goat anti Human Lambda Chain secondary antibody (Fab'2)

Mouse Anti-Human Ig Lambda antibody

STJ99555-100l 100 µl
EUR 91
Description: Unconjugated Mouse monoclonal to Human Ig Lambda antibody

Mouse Anti-Human Ig Lambda antibody

STJ99555-1mL 1 mL
EUR 514
Description: Unconjugated Mouse monoclonal to Human Ig Lambda antibody

Anti-Human lambda light chain antibody

STJ16100579 1 mL
EUR 290

Polyclonal Goat Anti-GOT2 (aa 295 to 306) Antibody

AMM04997G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 295 to 306) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-GOT2 (aa 360 to 373) Antibody

AMM04998G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GOT2 (aa 360 to 373) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 134 to 147) Antibody

AMM05956G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 134 to 147) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-Renalase (aa 224 to 233) Antibody

APG03367G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Renalase (aa 224 to 233) . This antibody is tested and proven to work in the following applications:

LAMBDA PLUS PIPETTOR 8 CHANNEL,1 TO 10UL

4080 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

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4081 1/pk
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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

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4082 1/pk
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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 8 CHANNEL,50 TO 300UL

4083 1/pk
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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 12 CHANNEL,1 TO 10UL

4084 1/pk
EUR 451
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS PIPETTOR 12 CHANNEL,5 TO 50UL

4085 1/pk
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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

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4087 1/pk
EUR 451
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

Anti-DNA pol lambda antibody

STJ92743 200 µl
EUR 197
Description: Rabbit polyclonal to DNA pol lambda.

Anti-Lambda Light Chain antibody

STJ16101015 100 µg
EUR 354

Goat F(Ab')2 Anti Human Lambda Light Chain Polyclonal Antibody,FITC

CPBT-65586GA 0.7 mg
EUR 715

Goat F(Ab')2 Anti Human Lambda Light Chain Polyclonal Antibody,HRP

CPBT-65592GA 1 ml
EUR 580

Goat F(Ab')2 Anti Human Lambda Light Chain Polyclonal Antibody,RPE

CPBT-65594GA 0.5 ml
EUR 741

Mouse anti Human IgG Lambda

40R-1014 500 ug
EUR 532
Description: Mouse anti Human IgG Lambda Light Chain secondary antibody

Anti-Human Lambda Light Chain

DB-039-0.1 100 μl
EUR 212
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Lambda Light Chain

DB-039-0.2 200 μl
EUR 298
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Lambda Light Chain

DB-039-0.5 500 μl
EUR 384
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Lambda Light Chain

DB-039-1 1 ml
EUR 613
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Anti-Human Lambda Light Chain

DB-039-RTU-15 15 ml
EUR 354
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Lambda Light Chain

DB-039-RTU-7 7 ml
EUR 231
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Lambda Light Chain

DB039RTU-15 15 ml
EUR 354
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Anti-Human Lambda Light Chain

DB039RTU-7 7 ml
EUR 231
Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use)

Mouse Anti-Human Lambda-HRP

LF-SA8054H 1.0 ml
EUR 384
Description: Mouse monoclonal to Human Lambda

Polyclonal Goat Anti-BDH2 / DHRS6 (aa 60 to 71) Antibody

AMM04910G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-BDH2 / DHRS6 (aa 60 to 71) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) Antibody

APG00100G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-EPB41L2 / 4.1G (aa 593 to 604) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) Antibody

APG00353G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-TUSC4 / NPRL2 (aa 140 to 151) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 273 to 284) Antibody

APR16228G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 273 to 284) . This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-C2GnT-M (aa 410 to 422) Antibody

APR16229G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-C2GnT-M (aa 410 to 422) . This antibody is tested and proven to work in the following applications:

Rat anti Human lambda light chain antibody

43R-1658 500 ug
EUR 357
Description: Purified Rat anti Human lambda light chain antibody

Mouse Anti-Human Ig Lambda antibody (AU)

STJ99386-100l 100 µl
EUR 81
Description: AU conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (AU)

STJ99386-1mL 1 mL
EUR 396
Description: AU conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (Biotin)

STJ99436-100l 100 µl
EUR 81
Description: Biotin conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (Biotin)

STJ99436-1mL 1 mL
EUR 396
Description: Biotin conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (FITC)

STJ99486-100l 100 µl
EUR 81
Description: FITC conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (FITC)

STJ99486-1mL 1 mL
EUR 396
Description: FITC conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (HRP)

STJ99536-100l 100 µl
EUR 81
Description: HRP conjugated Mouse monoclonal to Human Ig Lambda

Mouse Anti-Human Ig Lambda antibody (HRP)

STJ99536-1mL 1 mL
EUR 396
Description: HRP conjugated Mouse monoclonal to Human Ig Lambda

Anti-CD80 (Galiximab), Human IgG1, lambda Antibody

A2011-200 200 µg
EUR 682

Lambda Light Chain; Clone LcN-2 (Ready-To-Use)

A00155-0002 2 ml
EUR 87

Lambda Light Chain; Clone LcN-2 (Ready-To-Use)

A00155-0007 7 ml
EUR 142

Lambda Light Chain; Clone LcN-2 (Ready-To-Use)

A00155-0025 25 ml
EUR 327

LAMBDA PLUS SINGLE CHANNEL PIPETTOR,0.2 TO 2UL,AUTOCLAVABLE

4070 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

LAMBDA PLUS SINGLE CHANNEL PIPETTOR,0.5 TO 10UL,AUTOCLAVABLE

4071 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

LAMBDA PLUS SINGLE CHANNEL PIPETTORS,2 TO 20UL,AUTOCLAVABLE

4072 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

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4073 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

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4074 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

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4075 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-48T 48T
EUR 554
  • Should the Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

DLR-GOAT-Hu-96T 96T
EUR 725
  • Should the Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Ghrelin-O-Acyltransferase (GOAT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-48Tests 48 Tests
EUR 563

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RD-GOAT-Hu-96Tests 96 Tests
EUR 783

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-48Tests 48 Tests
EUR 589

Human Ghrelin-O-Acyltransferase (GOAT) ELISA Kit

RDR-GOAT-Hu-96Tests 96 Tests
EUR 820

OR Antibody

20-abx217389
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

OR Antibody

ABD10250 100 ug
EUR 438

OR Antibody

44609-100ul 100ul
EUR 252

OR Antibody

44609-50ul 50ul
EUR 187

OR Antibody

DF10250 200ul
EUR 304
Description: OR Antibody detects endogenous levels of total OR.

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-15 15 ml
EUR 322
  • What are the applications and the optimal dilutions of the product Antibody against PARP (Clone 10H)for analysis? - Immunocytochemistry : 5-20 ?g/ml | Western Blot (10 ?g/ml using colorimetric methods | <2 ?g/ml for ECL) | Immunoprecipitation and ELI
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Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

Goat IgG Secondary antibody Clone: pAb to UltraPolymer Goat Anti-Human IgG (H&L) HRP

A1278-5 5 ml
EUR 165
  • What are the applications and the optimal dilutions of the product Antibody against PARP (Clone 10H)for analysis? - Immunocytochemistry : 5-20 ?g/ml | Western Blot (10 ?g/ml using colorimetric methods | <2 ?g/ml for ECL) | Immunoprecipitation and ELI
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Description: Goat IgG Secondary antibody Clone: pAb against UltraPolymer Goat Anti-Human IgG (H&L) HRPfor application in IHC.The immunogen is Human IgG (H&L).This antibody can be used for detection of the target molecule in samples from Human.

LAMBDA Antibody

abx200540-100ug 100 ug
EUR 328
  • Shipped within 2-3 weeks.

Goat F(Ab')2 Anti Human Lambda Light Chain (Mouse Adsorbed) Polyclonal Antibody

DPBT-65596GA 0.5 mg
EUR 715

Anti-DNA Polymerase lambda/POLL Antibody

A00959-2 100ug/vial
EUR 294

Anti-Lambda Light chain Monoclonal Antibody

M13347 100ug
EUR 397
Description: Rabbit Monoclonal Lambda Light chain Antibody. Validated in IF, WB and tested in Human.

Anti-mouse Ig kappa lambda antibody

STJ15100203 250 µg
EUR 290
Description: These monoclonal antibodies enablel sensitive and specific detection of mouse immunoglobulin lambda light chains in e.g. ELISA and for enumeration of Ig producing cells using ELISpot.

Goat Interferon lambda-3 ELISA kit

E06I0499-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Interferon lambda-3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Interferon lambda-3 ELISA kit

E06I0499-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Interferon lambda-3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Interferon lambda-3 ELISA kit

E06I0499-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Goat Interferon lambda-3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Polyclonal Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) Antibody

APG00328G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) . This antibody is tested and proven to work in the following applications:

Monoclonal Mouse Anti-Human Ig Lambda

C010210-10mg 10mg
EUR 1114

Monoclonal Mouse Anti-Human Ig Lambda

C010210-1mg 1mg
EUR 269

Donkey anti Human Lambda light chain

20-S3001G000-S2 10 ml
EUR 192
Description: Donkey polyclonal anti Human Lambda Light Chain antibody

Lambda Light Chain (Lambda-IgLC) Antibody

abx411151-1mg 1 mg
EUR 551
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx411423-05mg 0.5 mg
EUR 662
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx413204-02mg 0.2 mg
EUR 565
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx414083-025mg 0.25 mg
EUR 565
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx415391-01mg 0.1 mg
EUR 509
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx415790-1mg 1 mg
EUR 439
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx415793-05mg 0.5 mg
EUR 398
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx415798-1mg 1 mg
EUR 551
  • Shipped within 1 week.

Lambda Light Chain (Lambda-IgLC) Antibody

abx415800-05mg 0.5 mg
EUR 398
  • Shipped within 1 week.

Mouse Anti Human Lambda Light Chain Monoclonal Antibody

CABT-48891MH 0.2 mg
EUR 741

Mouse Anti-Human Ig lambda chain Antibody (AF350)

abx142708-500ul 500 ul
EUR 328
  • Shipped within 5-10 working days.

Mouse Anti-Human Ig lambda chain Antibody (AF405)

abx142722-500ul 500 ul
EUR 328
  • Shipped within 5-10 working days.

Mouse Anti-Human Ig lambda chain Antibody (AF488)

abx142736-500ul 500 ul
EUR 328
  • Shipped within 5-10 working days.

Mouse Anti-Human Ig lambda chain Antibody (AF532)

abx142750-500ul 500 ul
EUR 328
  • Shipped within 5-10 working days.
Taxol reduces helper and cytotoxic lymphocytes causing systemic immunosuppression and myelosuppression in bone marrow, whereas 6SA does not decrease any immune cell subpopulations in circulating blood and lymph nodes. More importantly, the CoT decreased the Taxol-induced cytotoxicity in circulating T cells and bone marrow. Treatment with 6SA increases the secretion of IL-2, IL-12, GM-CSF, TNF-α and IFN-γ and significantly reduces IL-10 and IL-17 secretion, suggesting that the reduction of regulatory T cells and tumor-associated macrophages contribute to the host control of tumor development. Finally, 6SA has an effective antineoplastic activity against breast cancer cells in an immunocompetent animal, reduces the myelosuppression and leukopenia that Taxol produces, improves the antitumoral immunological microenvironment and increases the overall survival of the animals improving the quality of life of patients with cancer.

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