Foundation of the Istituto Toscano Tumori

ITT Cancer Research – Apoptosis – Oncology

Category: Peptides

Inhibition of microRNA-346 inhibits myocardial inflammation and apoptosis after myocardial infarction via targeting NFIB

Inhibition of microRNA-346 inhibits myocardial inflammation and apoptosis after myocardial infarction via targeting NFIB

Inhibition of microRNA-346 inhibits myocardial inflammation and apoptosis after myocardial infarction via targeting NFIB

Goal: Acute myocardial infarction (AMI) is a sudden cardiovascular occasion that endangers human life. MicroRNA is taken into account to be an vital participant within the pathophysiology of myocardial infarction (MI). This text goal was to…Continue Reading

Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4

Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4

Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4

Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait and has been shown to exhibit a diverse range of pharmacological properties. The aim of the present study was to investigate the…Continue Reading

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Purpose: Gastric carcinoma is the fourth principal cause of cancer-related deaths throughout the globe. There are inadequate clinical therapies for gastric cancer due to lack of operational drugs and ambiguity in molecular mechanisms. As such there…Continue Reading

MicroRNA-638 induces apoptosis and autophagy in human liver cancer cells by targeting enhancer of zeste homolog 2 (EZH2)

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells

Liver cancer is of the devastating human cancers and its incidence is increasing at an alarming rate. The clinical outcomes are far from descent due to lack of efficient therapeutic targets and chemotherapeutic agents. Studies…Continue Reading

Strongylocentrotus nudos Egg Polysaccharide induces autophagy and apoptosis in leukaemia cells by regulating mitochondrial function

Strongylocentrotus nudos Egg Polysaccharide induces autophagy and apoptosis in leukaemia cells by regulating mitochondrial function

Strongylocentrotus nudos Egg Polysaccharide induces autophagy and apoptosis in leukaemia cells by regulating mitochondrial function

In this study, we investigated the ability of the Polysaccharide from the Eggs of Strongylocentrotus nudus (SEP) to regulate cellular autophagy and apoptosis in leukaemia cells. Human acute myeloid leukaemia (AML) cells (HL60) and murine…Continue Reading