Foundation of the Istituto Toscano Tumori

ITT Cancer Research – Apoptosis – Oncology

Significance of halofuginone in esophageal squamous carcinoma cell apoptosis through HIF-1α-FOXO3a pathway

Significance of halofuginone in esophageal squamous carcinoma cell apoptosis through HIF-1α-FOXO3a pathway

  • Halofuginone (HF) from Dichroa febrifuga has proven therapeutic potential in hepatocellular, lung and colorectal most cancers cell fashions. Proof has additionally indicated that HF performs roles in caustic induced esophageal strictures and oxidative harm. Nonetheless, the position of HF in esophageal squamous carcinoma (ESCC) stays unclear.

 

  • On this research, we investigated HF actions and mechanisms throughout ESCC cell apoptosis. We noticed completely different HF concentrations (5, 10 and 20 nM) inhibited ESCC cell survival in a time and dose-dependent method. HF therapy markedly induced KYSE-30 and TE-1 cell apoptosis, and caspase-Three exercise. Apoptosis associated protein Bax expression was dramatically elevated, whereas Bcl-2 ranges had been decreased in KYSE-30 and TE-1 cells, after HF publicity.

 

  • Additionally, we confirmed that HF therapy induced DNA injury by selling γH2AX, pATM and pATR expression. HF therapy additionally decreased hypoxia-inducible factor-1α (HIF-1α) and forkhead field class O 3a (FOXO3a) expression in KYSE-30 and TE-1 cells. We additionally confirmed that HF inhibited FOXO3a expression, however this was depending on HIF-1α inhibition. Lastly, FOXO3a overexpression reversed HF induced cell survival inhibition, cell apoptosis and DNA injury.

gentaur

  • FOXO3a knockdown enhanced the results of HF on cell survival, cell apoptosis and DNA injury. In abstract, HF performs inhibitory roles in ESCC cell apoptosis, by way of HIF-1α-FOXO3a-dependent signaling. These knowledge help the notion that HF might act as an efficient therapeutic reagent in the direction of ESCC.
    Key phrases: DNA injury; Esophageal squamous carcinoma; FOXO3a; HIF-1α; Halofuginone.
Modulator Of Apoptosis 1 Protein
abx261949-5mg 5 mg
EUR 225
Human Modulator of apoptosis 1 (MOAP1)
1-CSB-EP014693HU
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Description: Recombinant Human Modulator of apoptosis 1(MOAP1) expressed in E.coli
Modulator of Apoptosis 1 (MOAP1) Antibody
20-abx006312
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  • 100 ul
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Modulator of Apoptosis 1 (MOAP1) Antibody
20-abx321726
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  • 100 ul
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Modulator of Apoptosis 1 (MOAP1) Antibody
abx321726-100g 100 µg
EUR 350
Modulator of Apoptosis 1 (MOAP1) Antibody
abx321726-50g 50 µg
EUR 237.5
Modulator of Apoptosis 1 (MOAP1) Antibody
abx376233-1096tests 10 × 96 tests Ask for price
Modulator of Apoptosis 1 (MOAP1) Antibody
abx376233-596tests 5 × 96 tests Ask for price
Modulator of Apoptosis 1 (MOAP1) Antibody
abx376233-96tests 96 tests
EUR 337.5
Modulator of Apoptosis 1 (MOAP1) Antibody
abx006312-100g 100 µg
EUR 275
Modulator of Apoptosis 1 (MOAP1) Antibody
abx006312-10g 10 µg
EUR 175
Modulator of Apoptosis 1 (MOAP1) Antibody
abx006312-200g 200 µg
EUR 387.5
Modulator Of Apoptosis 1 Human Recombinant
rAP-4060 Inquiry Ask for price
Recombinant Human Modulator Of Apoptosis 1
MBS145925-0005mg 0.005mg
EUR 240
Recombinant Human Modulator Of Apoptosis 1
MBS145925-002mg 0.02mg
EUR 310
Recombinant Human Modulator Of Apoptosis 1
MBS145925-1mg 1mg
EUR 3770
Recombinant Human Modulator Of Apoptosis 1
MBS145925-5x1mg 5x1mg
EUR 16645
Moap1 (Modulator of Apoptosis 1, MAP-1, MAP1)
MBS6002343-01mg 0.1(mg
EUR 550
Moap1 (Modulator of Apoptosis 1, MAP-1, MAP1)
MBS6002343-5x01mg 5x0.1mg
EUR 2330
Recombinant Human Modulator of apoptosis 1(MOAP1)
AP76800 1mg
EUR 1978
Recombinant Human Modulator of apoptosis 1 (MOAP1)
CSB-EP014693HU 1716 mg Ask for price
Recombinant Human Modulator of apoptosis 1 (MOAP1)
MBS1460749-002mgEColi 0.02mg(E-Coli)
EUR 255
Recombinant Human Modulator of apoptosis 1 (MOAP1)
MBS1460749-01mgEColi 0.1mg(E-Coli)
EUR 405
Recombinant Human Modulator of apoptosis 1 (MOAP1)
MBS1460749-1mgEColi 1mg(E-Coli)
EUR 1425
Recombinant Human Modulator of apoptosis 1 (MOAP1)
MBS1460749-5x1mgEColi 5x1mg(E-Coli)
EUR 6215
Recombinant Mouse Modulator of apoptosis 1 (Moap1)
MBS1401602-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1230
Recombinant Mouse Modulator of apoptosis 1 (Moap1)
MBS1401602-002mgEColi 0.02mg(E-Coli)
EUR 885
Recombinant Mouse Modulator of apoptosis 1 (Moap1)
MBS1401602-002mgYeast 0.02mg(Yeast)
EUR 1015
Recombinant Mouse Modulator of apoptosis 1 (Moap1)
MBS1401602-01mgEColi 0.1mg(E-Coli)
EUR 1065
Recombinant Mouse Modulator of apoptosis 1 (Moap1)
MBS1401602-01mgYeast 0.1mg(Yeast)
EUR 1160
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (PE)
MBS6187008-01mL 0.1(mL
EUR 875
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (PE)
MBS6187008-5x01mL 5x0.1mL
EUR 3800
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (AP)
MBS6164958-01mL 0.1(mL
EUR 875
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (AP)
MBS6164958-5x01mL 5x0.1mL
EUR 3800
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (HRP)
MBS6182598-01mL 0.1(mL
EUR 875
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (HRP)
MBS6182598-5x01mL 5x0.1mL
EUR 3800
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (APC)
MBS6169368-01mL 0.1(mL
EUR 875
MOAP1 (Modulator of Apoptosis 1, MAP-1, PNMA4) (APC)
MBS6169368-5x01mL 5x0.1mL
EUR 3800
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
abx389916-96tests 96 tests
EUR 1093.2
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
abx385167-96tests 96 tests
EUR 1093.2
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
EK9460 96Т
EUR 799
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
EK9462 96Т
EUR 799
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33217MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33217MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33219HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33219HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)
Human Modulator of apoptosis 1, MOAP1 ELISA KIT
ELI-20830h 96tests
EUR 696
Mouse Modulator of apoptosis 1, Moap1 ELISA KIT
ELI-20831m 96tests
EUR 736
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
KTE61574-48T 48T
EUR 339
Description: This Human Modulator of apoptosis 1 (MOAP1) ELISA Kit employs a two-site sandwich ELISA to quantitate MOAP1.
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
KTE61574-96T 96T
EUR 589
Description: This Human Modulator of apoptosis 1 (MOAP1) ELISA Kit employs a two-site sandwich ELISA to quantitate MOAP1.
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
KTE61574-96T5 96 T×5
EUR 2629
Description: This Human Modulator of apoptosis 1 (MOAP1) ELISA Kit employs a two-site sandwich ELISA to quantitate MOAP1.
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
KTE61574-96T50 96 T×50
EUR 24569
Description: This Human Modulator of apoptosis 1 (MOAP1) ELISA Kit employs a two-site sandwich ELISA to quantitate MOAP1.
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33217MO-48T 48T
EUR 325
Description: Mouse (Mus musculus)
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33217MO-96T 96T
EUR 610
Description: Mouse (Mus musculus)
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33219HU-48T 48T
EUR 325
Description: Human (Homo sapiens)
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
AE33219HU-96T 96T
EUR 610
Description: Human (Homo sapiens)
Mouse Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9337437-10x96StripWells 10x96-Strip-Wells
EUR 6725
Mouse Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9337437-48StripWells 48-Strip-Wells
EUR 550
Mouse Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9337437-5x96StripWells 5x96-Strip-Wells
EUR 3420
Mouse Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9337437-96StripWells 96-Strip-Wells
EUR 765
Human Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9318286-10x96StripWells 10x96-Strip-Wells
EUR 6725
Human Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9318286-48StripWells 48-Strip-Wells
EUR 550
Human Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9318286-5x96StripWells 5x96-Strip-Wells
EUR 3420
Human Modulator of apoptosis 1, MOAP1 ELISA Kit
MBS9318286-96StripWells 96-Strip-Wells
EUR 765
Human Modulator Of Apoptosis 1 (MOAP1) ELISA Kit
MBS9715238-48Tests 48Tests
EUR 340

 

TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis by way of NF-κB signaling pathway

Goals: Uterine leiomyoma (UM) is the commonest benign gynecological tumor and the main indication for hysterectomy. Our research explored the roles of TRIM9 in leiomyoma formation and investigated the underlying molecular mechanisms.
Materials and strategies: The connection between TRIM9 expression and fibroids formation was deciphered from the GEO database after bioinformatics evaluation and recognized by qPCR in human leiomyoma tissues. Each TRIM9 mRNA and protein expression had been additional detected in main cultured uterine leiomyoma cells (UMC). The tumorigenesis potentials of TRIM9 in cell proliferation, cell cycle, cell apoptosis; cyclin D1, survivin and cleaved-caspase Three protein expressions in main UMC with TRIM9 overexpression (UMC-oeTRIM9); and uterine easy muscle cells (SMC) with TRIM9 knockdown (SMC-siTRIM9) had been evaluated in vitro. NF-kB p65 and its phosphorylation had been additional examined by western blotting, and rescue experiments on cell proliferation, cell cycle and cell apoptosis had been performed.
Key findings: TRIM9 confirmed greater expression in UM tissue and UMC in contrast with regular myometrium. The overexpression of TRIM9 in UMC notably promoted UM progress by way of enhancement of cell proliferation, discount of cell apoptosis, and regulation of cyclin D1, survivin, cleaved-caspase 3, and nuclear NF-κB expression, which had been reversed in SMC-siTRIM9 and PDTC (an NF-κB inhibitor) intervention in UMC-oeTRIM9.
 

THAP Domain Containing, Apoptosis Associated Protein 3 Protein
abx262679-5mg 5 mg
EUR 225

THAP Domain Containing, Apoptosis Associated Protein 1 Protein
20-abx261909
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THAP Domain Containing, Apoptosis Associated Protein 7 Protein
20-abx261330
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  • 1 mg
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THAP Domain Containing, Apoptosis Associated Protein 7 Protein
abx261330-100g 100 µg
EUR 325

THAP Domain Containing, Apoptosis Associated Protein 7 Protein
abx261330-20g 20 µg
EUR 225

THAP Domain Containing, Apoptosis Associated Protein 1 Protein
abx261909-10mg 10 mg
EUR 4625

THAP Domain Containing, Apoptosis Associated Protein 1 Protein
abx261909-5mg 5 mg
EUR 325

THAP Domain Containing, Apoptosis Associated Protein 3 Human Recombinant
rAP-4937 Inquiry Ask for price

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 3
MBS145602-0002mg 0.002mg
EUR 240

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 3
MBS145602-001mg 0.01mg
EUR 310

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 3
MBS145602-1mg 1mg
EUR 5345

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 3
MBS145602-5x1mg 5x1mg
EUR 23725

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (AP)
MBS6440543-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (AP)
MBS6440543-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (PE)
MBS6440553-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (PE)
MBS6440553-5x01mL 5x0.1mL
EUR 4120

THAP3 THAP Domain Containing, Apoptosis Associated Protein 3 Human Recombinant Protein
PROTQ8WTV1 Regular: 10ug
EUR 380.4
Description: THAP3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-239) and having a molecular mass of 29.4kDa.

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (APC)
MBS6440544-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (APC)
MBS6440544-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (HRP)
MBS6440547-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (HRP)
MBS6440547-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (FITC)
MBS6440546-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (FITC)
MBS6440546-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (Biotin)
MBS6440545-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (Biotin)
MBS6440545-5x01mL 5x0.1mL
EUR 4120

Thap3 (GFP-tagged) - Mouse THAP domain containing, apoptosis associated protein 3 (Thap3)
MG202471 10 µg Ask for price

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 405)
MBS6440548-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 405)
MBS6440548-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 490)
MBS6440549-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 490)
MBS6440549-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 550)
MBS6440550-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 550)
MBS6440550-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 650)
MBS6440551-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 650)
MBS6440551-5x01mL 5x0.1mL
EUR 4120

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 750)
MBS6440552-01mL 0.1mL
EUR 950

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) (MaxLight 750)
MBS6440552-5x01mL 5x0.1mL
EUR 4120

THAP Domain Containing, Apoptosis Associated Protein 1 Human Recombinant
rAP-4936 Inquiry Ask for price

THAP Domain Containing, Apoptosis Associated Protein 7 Human Recombinant
rAP-4938 Inquiry Ask for price

THAP Domain Containing, Apoptosis Associated Protein 11 Human Recombinant
rAP-4939 Inquiry Ask for price

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 7
MBS146378-0005mg 0.005mg
EUR 240

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 7
MBS146378-002mg 0.02mg
EUR 310

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 7
MBS146378-1mg 1mg
EUR 2880

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 7
MBS146378-5x1mg 5x1mg
EUR 12630

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1
MBS144781-0005mg 0.005mg
EUR 240

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1
MBS144781-002mg 0.02mg
EUR 310

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1
MBS144781-1mg 1mg
EUR 3770

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1
MBS144781-5x1mg 5x1mg
EUR 16645

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 11
MBS145912-0002mg 0.002mg
EUR 240

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 11
MBS145912-001mg 0.01mg
EUR 310

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 11
MBS145912-1mg 1mg
EUR 5345

Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 11
MBS145912-5x1mg 5x1mg
EUR 23725

Thap3 (untagged ORF) - Rat THAP domain containing, apoptosis associated protein 3 (Thap3), (10 ug)
RN209842 10 µg Ask for price

THAP1 THAP Domain Containing, Apoptosis Associated Protein 1 Human Recombinant Protein
PROTQ9NVV9 Regular: 20ug
EUR 380.4
Description: THAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa.;THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

THAP11 THAP Domain Containing, Apoptosis Associated Protein 11 Human Recombinant Protein
PROTQ96EK4 Regular: 10ug
EUR 380.4
Description: THAP11 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-314) and having a molecular mass of 36.8kDa.;THAP11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

THAP7 THAP Domain Containing, Apoptosis Associated Protein 7 Human Recombinant Protein
PROTQ9BT49 Regular: 20ug
EUR 380.4
Description: THAP7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-309 a.a) and having a molecular mass of 36.8kDa. ;THAP7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

THAP2 (untagged)-Human THAP domain containing, apoptosis associated protein 2 (THAP2)
SC319187 10 µg Ask for price

3`UTR clone of THAP domain containing apoptosis associated protein 3 (THAP3) for miRNA target validation
SC214920 10 µg Ask for price

THAP3 (GFP-tagged) - Human THAP domain containing, apoptosis associated protein 3 (THAP3), transcript variant 3
RG230782 10 µg Ask for price

Thap3 (Myc-DDK-tagged ORF) - Rat THAP domain containing, apoptosis associated protein 3 (Thap3), (10 ug)
RR209842 10 µg Ask for price

Thap2 (untagged) - Mouse THAP domain containing, apoptosis associated protein 2 (Thap2), (10ug)
MC201399 10 µg Ask for price

Thap1 (GFP-tagged) - Mouse THAP domain containing, apoptosis associated protein 1 (Thap1)
MG202256 10 µg Ask for price

Thap2 (GFP-tagged) - Mouse THAP domain containing, apoptosis associated protein 2 (Thap2)
MG202417 10 µg Ask for price

THAP2 (GFP-tagged) - Human THAP domain containing, apoptosis associated protein 2 (THAP2)
RG203590 10 µg Ask for price

THAP3 (untagged)-Human THAP domain containing, apoptosis associated protein 3 (THAP3), transcript variant 2
SC309251 10 µg Ask for price

Goat Apoptosis associated speck like protein containing a CARD(PYCARD) ELISA kit
E01A45000 96T
EUR 700
Description: ELISA

Rat Apoptosis associated speck like protein containing a CARD(PYCARD) ELISA kit
E02A1947-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis associated speck like protein containing a CARD(PYCARD) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptosis associated speck like protein containing a CARD(PYCARD) ELISA kit
E02A1947-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis associated speck like protein containing a CARD(PYCARD) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Significance: To our data, this was the primary research demonstrating the roles of TRIM9 in cell progress development of UM improvement. TRIM9 could also be a possible therapeutic goal for UM, by selling leiomyoma cell proliferation and lowering cell apoptosis by way of activation of the NF-κB pathway.
Key phrases: Cell apoptosis; Cell proliferation; NF-κB signaling pathway; TRIM9; Uterine leiomyoma.