Foundation of the Istituto Toscano Tumori

ITT Cancer Research – Apoptosis – Oncology

Significance of halofuginone in esophageal squamous carcinoma cell apoptosis through HIF-1α-FOXO3a pathway

Significance of halofuginone in esophageal squamous carcinoma cell apoptosis through HIF-1α-FOXO3a pathway

  • Halofuginone (HF) from Dichroa febrifuga has proven therapeutic potential in hepatocellular, lung and colorectal most cancers cell fashions. Proof has additionally indicated that HF performs roles in caustic induced esophageal strictures and oxidative harm. Nonetheless, the position of HF in esophageal squamous carcinoma (ESCC) stays unclear.

 

  • On this research, we investigated HF actions and mechanisms throughout ESCC cell apoptosis. We noticed completely different HF concentrations (5, 10 and 20 nM) inhibited ESCC cell survival in a time and dose-dependent method. HF therapy markedly induced KYSE-30 and TE-1 cell apoptosis, and caspase-Three exercise. Apoptosis associated protein Bax expression was dramatically elevated, whereas Bcl-2 ranges had been decreased in KYSE-30 and TE-1 cells, after HF publicity.

 

  • Additionally, we confirmed that HF therapy induced DNA injury by selling γH2AX, pATM and pATR expression. HF therapy additionally decreased hypoxia-inducible factor-1α (HIF-1α) and forkhead field class O 3a (FOXO3a) expression in KYSE-30 and TE-1 cells. We additionally confirmed that HF inhibited FOXO3a expression, however this was depending on HIF-1α inhibition. Lastly, FOXO3a overexpression reversed HF induced cell survival inhibition, cell apoptosis and DNA injury.

gentaur

  • FOXO3a knockdown enhanced the results of HF on cell survival, cell apoptosis and DNA injury. In abstract, HF performs inhibitory roles in ESCC cell apoptosis, by way of HIF-1α-FOXO3a-dependent signaling. These knowledge help the notion that HF might act as an efficient therapeutic reagent in the direction of ESCC.
    Key phrases: DNA injury; Esophageal squamous carcinoma; FOXO3a; HIF-1α; Halofuginone.
Human Modulator of apoptosis 1 (MOAP1)
1-CSB-EP014693HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Modulator of apoptosis 1(MOAP1) expressed in E.coli
Modulator of apoptosis 1 (MOAP1) polyclonal antibody
ABP-PAB-10271 100 ug Ask for price
Human Modulator of apoptosis 1, MOAP1 ELISA KIT
ELI-20830h 96 Tests
EUR 824
Mouse Modulator of apoptosis 1, Moap1 ELISA KIT
ELI-20831m 96 Tests
EUR 865
Human Modulator of apoptosis 1 (MOAP1) ELISA Kit
abx385167-96tests 96 tests
EUR 911
Mouse Modulator of apoptosis 1 (MOAP1) ELISA Kit
abx389916-96tests 96 tests
EUR 911
MOAP1 Modulator Of Apoptosis 1 Human Recombinant Protein
PROTQ96BY2 Regular: 20ug
EUR 317
Description: MOAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 374 amino acids (1-351a.a) and having a molecular mass of 41.9kDa.MOAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
P53 Upregulated Modulator of Apoptosis (PUMA) Antibody
20-abx104029
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
p53 Upregulated Modulator of Apoptosis (PUMA) Antibody
20-abx104030
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
P53 Upregulated Modulator of Apoptosis (PUMA) Antibody
20-abx008195
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
p53 Upregulated Modulator Of Apoptosis (PUMA) Antibody
20-abx173936
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
p53 Upregulated Modulator Of Apoptosis (PUMA) Antibody
20-abx173937
  • EUR 871.00
  • EUR 453.00
  • 1 mg
  • 200 ug
P53 Upregulated Modulator of Apoptosis (PUMA) Antibody
abx236956-100ug 100 ug
EUR 481
Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA)
4-RPB909Ra01
  • EUR 528.29
  • EUR 244.00
  • EUR 1706.08
  • EUR 635.36
  • EUR 1170.72
  • EUR 416.00
  • EUR 4115.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat p53 Upregulated Modulator Of Apoptosis expressed in: E.coli
Mouse modulator of apoptosis 1 (MOAP1) Control/blocking peptide
AB-23039-P 100ug
EUR 164
ELISA kit for Human Modulator of apoptosis 1 (MOAP1)
KTE61574-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Modulator of apoptosis 1 (MOAP1)
KTE61574-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Modulator of apoptosis 1 (MOAP1)
KTE61574-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Modulator of apoptosis 1 (MOAP1)
KTE70988-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Modulator of apoptosis 1 (MOAP1)
KTE70988-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse Modulator of apoptosis 1 (MOAP1)
KTE70988-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Modulator of apoptosis 1 (MOAP1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Human p53 Upregulated Modulator Of Apoptosis (PUMA) Protein
20-abx654646
  • EUR 662.00
  • EUR 272.00
  • EUR 2040.00
  • EUR 787.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Rat P53 Upregulated Modulator Of Apoptosis ELISA kit
E02P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat P53 Upregulated Modulator Of Apoptosis ELISA kit
E02P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat P53 Upregulated Modulator Of Apoptosis ELISA kit
E02P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse P53 Upregulated Modulator Of Apoptosis ELISA kit
E03P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse P53 Upregulated Modulator Of Apoptosis ELISA kit
E03P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse P53 Upregulated Modulator Of Apoptosis ELISA kit
E03P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit P53 Upregulated Modulator Of Apoptosis ELISA kit
E04P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Rabbit P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit P53 Upregulated Modulator Of Apoptosis ELISA kit
E04P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Rabbit P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit P53 Upregulated Modulator Of Apoptosis ELISA kit
E04P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human P53 Upregulated Modulator Of Apoptosis ELISA kit
E01P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human P53 Upregulated Modulator Of Apoptosis ELISA kit
E01P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Human P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human P53 Upregulated Modulator Of Apoptosis ELISA kit
E01P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Human P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat P53 Upregulated Modulator Of Apoptosis ELISA kit
E06P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat P53 Upregulated Modulator Of Apoptosis ELISA kit
E06P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat P53 Upregulated Modulator Of Apoptosis ELISA kit
E06P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E07P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E07P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E07P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog P53 Upregulated Modulator Of Apoptosis ELISA kit
E08P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog P53 Upregulated Modulator Of Apoptosis ELISA kit
E08P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog P53 Upregulated Modulator Of Apoptosis ELISA kit
E08P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey P53 Upregulated Modulator Of Apoptosis ELISA kit
E09P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Monkey P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey P53 Upregulated Modulator Of Apoptosis ELISA kit
E09P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Monkey P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey P53 Upregulated Modulator Of Apoptosis ELISA kit
E09P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat p53 Upregulated Modulator Of Apoptosis (PUMA) Protein
20-abx168786
  • EUR 732.00
  • EUR 286.00
  • EUR 2291.00
  • EUR 871.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA)
4-CPB909Hu21
  • EUR 221.86
  • EUR 162.00
  • EUR 556.96
  • EUR 252.32
  • EUR 404.64
  • EUR 211.00
  • EUR 1242.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human p53 Upregulated Modulator Of Apoptosis expressed in: chemical synthesis
Moap1 ELISA Kit| Mouse Modulator of apoptosis 1 ELISA Kit
EF015555 96 Tests
EUR 689
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-100ug
QP6372-ec-100ug 100ug
EUR 408
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-10ug
QP6372-ec-10ug 10ug
EUR 200
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-1mg
QP6372-ec-1mg 1mg
EUR 1632
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-200ug
QP6372-ec-200ug 200ug
EUR 634
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-500ug
QP6372-ec-500ug 500ug
EUR 1060
Recombinant Human Modulator of apoptosis 1 Protein, GST, E.coli-50ug
QP6372-ec-50ug 50ug
EUR 263
Pig P53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
abx360761-96tests 96 tests
EUR 825
Rabbit P53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
abx362702-96tests 96 tests
EUR 825
Sheep P53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
abx364339-96tests 96 tests
EUR 926
Rat P53 Upregulated Modulator of Apoptosis (PUMA) ELISA Kit
abx570696-96tests 96 tests
EUR 786
Human P53 Upregulated Modulator of Apoptosis (PUMA) Protein (OVA)
20-abx651270
  • EUR 314.00
  • EUR 203.00
  • EUR 773.00
  • EUR 342.00
  • EUR 258.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Guinea pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E05P0745-192T 192 tests
EUR 1270
Description: A sandwich ELISA for quantitative measurement of Guinea pig P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E05P0745-48 1 plate of 48 wells
EUR 520
Description: A sandwich ELISA for quantitative measurement of Guinea pig P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Guinea pig P53 Upregulated Modulator Of Apoptosis ELISA kit
E05P0745-96 1 plate of 96 wells
EUR 685
Description: A sandwich ELISA for quantitative measurement of Guinea pig P53 Upregulated Modulator Of Apoptosis in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human p53 up- regulated modulator of apoptosis ELISA Kit
ELA-E1909h 96 Tests
EUR 824
Human PUMA(P53 Upregulated Modulator of Apoptosis) ELISA Kit
EH0250 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

 

TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis by way of NF-κB signaling pathway

Goals: Uterine leiomyoma (UM) is the commonest benign gynecological tumor and the main indication for hysterectomy. Our research explored the roles of TRIM9 in leiomyoma formation and investigated the underlying molecular mechanisms.
Materials and strategies: The connection between TRIM9 expression and fibroids formation was deciphered from the GEO database after bioinformatics evaluation and recognized by qPCR in human leiomyoma tissues. Each TRIM9 mRNA and protein expression had been additional detected in main cultured uterine leiomyoma cells (UMC). The tumorigenesis potentials of TRIM9 in cell proliferation, cell cycle, cell apoptosis; cyclin D1, survivin and cleaved-caspase Three protein expressions in main UMC with TRIM9 overexpression (UMC-oeTRIM9); and uterine easy muscle cells (SMC) with TRIM9 knockdown (SMC-siTRIM9) had been evaluated in vitro. NF-kB p65 and its phosphorylation had been additional examined by western blotting, and rescue experiments on cell proliferation, cell cycle and cell apoptosis had been performed.
Key findings: TRIM9 confirmed greater expression in UM tissue and UMC in contrast with regular myometrium. The overexpression of TRIM9 in UMC notably promoted UM progress by way of enhancement of cell proliferation, discount of cell apoptosis, and regulation of cyclin D1, survivin, cleaved-caspase 3, and nuclear NF-κB expression, which had been reversed in SMC-siTRIM9 and PDTC (an NF-κB inhibitor) intervention in UMC-oeTRIM9.
 

Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 Protein
20-abx261284
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

THAP Domain Containing, Apoptosis Associated Protein 7 Protein
20-abx261330
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

THAP Domain Containing, Apoptosis Associated Protein 1 Protein
20-abx261909
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

THAP3 THAP Domain Containing, Apoptosis Associated Protein 3 Human Recombinant Protein
PROTQ8WTV1 Regular: 10ug
EUR 317
Description: THAP3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-239) and having a molecular mass of 29.4kDa.

Recombinant Apoptosis Associated Tyrosine Kinase (AATK)
4-RPA429Hu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Apoptosis Associated Tyrosine Kinase expressed in: E.coli

Recombinant Apoptosis Associated Tyrosine Kinase (AATK)
4-RPA429Mu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Apoptosis Associated Tyrosine Kinase expressed in: E.coli

Recombinant Human MMP-3 Protein
PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

IL-3 Interleukin-3 Human Recombinant Protein, His Tag
PROTP08700-3 Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Pycard ELISA Kit| Mouse Apoptosis-associated speck-like protein
EF016005 96 Tests
EUR 689

Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptosis Associated Tyrosine Kinase ELISA kit
E08A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptosis Associated Tyrosine Kinase ELISA kit
E08A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Apoptosis Associated Tyrosine Kinase ELISA kit
E08A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptosis Associated Tyrosine Kinase ELISA kit
E07A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptosis Associated Tyrosine Kinase ELISA kit
E07A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Apoptosis Associated Tyrosine Kinase ELISA kit
E07A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

BCL2 Associated X, Apoptosis Regulator (BAX) Antibody
20-abx159342
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug

BCL2 Associated X, Apoptosis Regulator (BAX) Antibody
20-abx159343
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant
PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

THAP1 THAP Domain Containing, Apoptosis Associated Protein 1 Human Recombinant Protein
PROTQ9NVV9 Regular: 20ug
EUR 317
Description: THAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa.;THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

THAP11 THAP Domain Containing, Apoptosis Associated Protein 11 Human Recombinant Protein
PROTQ96EK4 Regular: 10ug
EUR 317
Description: THAP11 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-314) and having a molecular mass of 36.8kDa.;THAP11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

THAP7 THAP Domain Containing, Apoptosis Associated Protein 7 Human Recombinant Protein
PROTQ9BT49 Regular: 20ug
EUR 317
Description: THAP7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-309 a.a) and having a molecular mass of 36.8kDa. ;THAP7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Apoptosis-Associated Speck-Like Protein Containing A CARD (ASC) Antibody
20-abx141032
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Apoptosis-Associated Speck-Like Protein Containing A CARD (ASC) Antibody
20-abx013852
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Mouse Apoptosis-associated speck-like protein containing a CARD (Pycard)
1-CSB-EP861664MO
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Apoptosis-associated speck-like protein containing a CARD(Pycard) expressed in E.coli

Human Apoptosis-associated speck-like protein containing a CARD (PYCARD)
1-CSB-EP890936HU
  • EUR 505.00
  • EUR 265.00
  • EUR 1827.00
  • EUR 766.00
  • EUR 1218.00
  • EUR 335.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Apoptosis-associated speck-like protein containing a CARD(PYCARD) expressed in E.coli

AIFM1 Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 Human Recombinant Protein
PROTO95831 Regular: 20ug
EUR 317
Description: AIFM1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 537 amino acids (98-609) and having a molecular mass of 58.5 kDa.;AIFM1 is fused to a 25 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Apoptosis-Related Protein 3 (APR3) Antibody
20-abx148264
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Guinea pig Apoptosis Associated Tyrosine Kinase ELISA kit
E05A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Apoptosis Associated Tyrosine Kinase ELISA kit
E05A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Apoptosis Associated Tyrosine Kinase ELISA kit
E05A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx125507
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx119426
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
abx037791-100ug 100 ug
EUR 391

Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx326339
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse)
4-PAA429Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK)

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein
PROTQ9Y5C1-3 Regular: 10ug
EUR 317
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9
PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody
M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

ELISA kit for Mouse AATK (Apoptosis Associated Tyrosine Kinase)
E-EL-M0140 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse AATK (Apoptosis Associated Tyrosine Kinase) in samples from Serum, Plasma, Cell supernatant

PYCARD ELISA Kit| Bovine Apoptosis-associated speck-like protei
EF011822 96 Tests
EUR 689

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), APC
4-PAA429Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC.

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), Biotinylated
4-PAA429Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Biotin.

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), Cy3
4-PAA429Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Cy3.

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), FITC
4-PAA429Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with FITC.

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), HRP
4-PAA429Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with HRP.

Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), PE
4-PAA429Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with PE.

Microfibrillar-associated Protein 3 Protein
20-abx261305
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug

Goat Apoptosis related protein 3 ELISA kit
E06A1796-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis related protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Apoptosis related protein 3 ELISA kit
E06A1796-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis related protein 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Significance: To our data, this was the primary research demonstrating the roles of TRIM9 in cell progress development of UM improvement. TRIM9 could also be a possible therapeutic goal for UM, by selling leiomyoma cell proliferation and lowering cell apoptosis by way of activation of the NF-κB pathway.
Key phrases: Cell apoptosis; Cell proliferation; NF-κB signaling pathway; TRIM9; Uterine leiomyoma.