Foundation of the Istituto Toscano Tumori

ITT Cancer Research – Apoptosis – Oncology

A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis

A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis
Goal: This research aimed to discover the impact of GANT61 on regulating cell proliferation, cell apoptosis and cell cycle, and to research whether or not GANT61 would perform in a number of myeloma (MM) by way of inhibiting Notch pathway.
Strategies: RPMI-8226 and U266 cells had been handled by GANT61 (0, 2.5, 5.0, 10.0, 20.0, 30.0, 40.0, 50.Zero μmol/L) for 18, 24 and 36 hours (h), and cell proliferation was detected by Cell Counting Package 8. Then these cells had been handled by GANT61 at 0, 2.5, 5.0, 10.Zero μmol/L for 24 h or handled by 10.Zero μmol/L GANT61 for 0, 18, 24 and 36 h, and cell apoptosis charge, apoptosis markers and cell cycle had been detected by AV/PI, Western blot, and PI staining. Notch1, Jagged1, Jagged2 and Hes1 expressions had been detected by qPCR and Western blot. Additional rescue experiments had been performed by upregulating Notch1.
Outcomes: In RPMI-8226 and U266 cells, GANT61 inhibited cell proliferation, elevated cell apoptosis charge and cell proportion of G1/G0 part whereas decreased cell proportion of S part in a dose- and time-dependent method. Apart from, GANT61 inhibited Notch1, Jagged1, Jagged2 and Hes1 expressions in a dose- and time-dependent method as effectively. In rescue experiments, Notch1 upregulation attenuated the inhibition of cell proliferation, promotion of cell apoptosis, induction of G1/G0 cycle retardation and repression of Notch signaling pathway induced by GANT61 therapy in RPMI-8226 and U266 cells.
 Conclusions: GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent method by inhibiting Notch pathway in MM.
gentaur
Abbreviations: MM: A number of myeloma; Hh: Hedgehog; EMT: epithelial mesenchymal transition; AML: acute myeloid leukemia; GANT61: GLI antagonist; DMSO: dimethyl sulfoxide; CCK-8: Cell Counting Package 8; C-Caspase 3: Cleaved Caspase 3; Bcl-2: B-cell lymphoma-2; RT-qPCR: real-time quantitative polymerase chain response; OD: optical density; PTCH1: Patched1.
Key phrases: GANT61; A number of myeloma; apoptosis; cell cycle; notch; proliferation.
 
THAP Domain Containing, Apoptosis Associated Protein 1 Protein
20-abx261909
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), APC
4-PAA429Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), Biotinylated
4-PAA429Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Biotin.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), Cy3
4-PAA429Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Cy3.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), FITC
4-PAA429Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with FITC.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), HRP
4-PAA429Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with HRP.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), PE
4-PAA429Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with PE.
Death-associated protein 1 Polyclonal Antibody
42204-100ul 100ul
EUR 333
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA429Mu01-APC-Cy7
  • EUR 538.00
  • EUR 5962.00
  • EUR 1588.00
  • EUR 713.00
  • EUR 304.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC-Cy7.
BCL2 Associated X, Apoptosis Regulator (BAX) Antibody
20-abx159342
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug
BCL2 Associated X, Apoptosis Regulator (BAX) Antibody
20-abx159343
  • EUR 272.00
  • EUR 230.00
  • 100 ug
  • 50 ug
DiscoveryProbe? Apoptosis Compound Library
L1036-.1 100 uL/well(10 mM solution)
EUR 3472
Human KRAB-associated Protein 1 (KAP-1) AssayMax ELISA Kit
EK2802-1 96 Well Plate
EUR 477
Modulator of apoptosis 1 (MOAP1) polyclonal antibody
ABP-PAB-10271 100 ug Ask for price
THAP Domain Containing, Apoptosis Associated Protein 7 Protein
20-abx261330
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
THAP Domain Containing, Apoptosis Associated Protein 3 Protein
20-abx262679
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
AIFM1 Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 Human Recombinant Protein
PROTO95831 Regular: 20ug
EUR 317
Description: AIFM1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 537 amino acids (98-609) and having a molecular mass of 58.5 kDa.;AIFM1 is fused to a 25 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig)
4-PAA429Hu01
  • EUR 232.00
  • EUR 2272.00
  • EUR 571.00
  • EUR 288.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK)
THAP1 THAP Domain Containing, Apoptosis Associated Protein 1 Human Recombinant Protein
PROTQ9NVV9 Regular: 20ug
EUR 317
Description: THAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa.;THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
HCLS1-associated protein X-1 Polyclonal Antibody
42396-100ul 100ul
EUR 333
Death-associated protein 1 Polyclonal Conjugated Antibody
C42204 100ul
EUR 397
Telomerase-associated protein 1 (TEP1) polyclonal antibody
ABP-PAB-02284 100 ug Ask for price
BAI1-associated protein 1 (BAIAP1) polyclonal antibody
ABP-PAB-10426 100 ug Ask for price
Huntingtin-associated protein 1 (HAP1) polyclonal antibody
ABP-PAB-10627 100 ug Ask for price
PDGFA associated protein 1 (PDAP1) polyclonal antibody
ABP-PAB-11259 100 ug Ask for price
Recombinant Apoptosis Associated Tyrosine Kinase (AATK)
4-RPA429Hu01
  • EUR 467.36
  • EUR 228.00
  • EUR 1477.60
  • EUR 559.20
  • EUR 1018.40
  • EUR 376.00
  • EUR 3544.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Apoptosis Associated Tyrosine Kinase expressed in: E.coli
Recombinant Apoptosis Associated Tyrosine Kinase (AATK)
4-RPA429Mu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Apoptosis Associated Tyrosine Kinase expressed in: E.coli
Polyclonal Prostate Apoptosis Response protein-4 Antibody
AMR09562G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Prostate Apoptosis Response protein-4 . This antibody is tested and proven to work in the following applications:
Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx119426
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx125507
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
abx037791-100ug 100 ug
EUR 391
Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
20-abx326339
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
Apoptosis-Associated Speck-Like Protein Containing A CARD (ASC) Antibody
20-abx141032
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
Apoptosis-Associated Speck-Like Protein Containing A CARD (ASC) Antibody
20-abx013852
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), APC
4-PAA429Hu01-APC
  • EUR 323.00
  • EUR 2951.00
  • EUR 831.00
  • EUR 407.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), Biotinylated
4-PAA429Hu01-Biotin
  • EUR 295.00
  • EUR 2222.00
  • EUR 668.00
  • EUR 357.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Biotin.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), Cy3
4-PAA429Hu01-Cy3
  • EUR 389.00
  • EUR 3893.00
  • EUR 1067.00
  • EUR 501.00
  • EUR 237.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Cy3.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), FITC
4-PAA429Hu01-FITC
  • EUR 278.00
  • EUR 2380.00
  • EUR 685.00
  • EUR 346.00
  • EUR 187.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with FITC.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), HRP
4-PAA429Hu01-HRP
  • EUR 296.00
  • EUR 2574.00
  • EUR 737.00
  • EUR 369.00
  • EUR 198.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with HRP.
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), PE
4-PAA429Hu01-PE
  • EUR 278.00
  • EUR 2380.00
  • EUR 685.00
  • EUR 346.00
  • EUR 187.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with PE.
MORF4 family-associated protein 1-like 1 Polyclonal Antibody
42258-100ul 100ul
EUR 333
DNA methyltransferase 1 associated protein 1 (DMAP1) polyclonal antibody
ABP-PAB-10615 100 ug Ask for price
HCLS1-associated protein X-1 Polyclonal Conjugated Antibody
C42396 100ul
EUR 397
GRB2-associated binding protein 1 (GAB1) polyclonal antibody
ABP-PAB-10688 100 ug Ask for price
Insulinoma Associated Protein 1 (INSM1) Polyclonal Antibody (Mouse)
4-PAD877Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Insulinoma Associated Protein 1 (INSM1)
Ubiquitin Associated Protein 1 (UBAP1) Polyclonal Antibody (Human)
4-PAC583Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Ubiquitin Associated Protein 1 (UBAP1)
Ubiquitin Associated Protein 1 (UBAP1) Polyclonal Antibody (Mouse)
4-PAC583Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Ubiquitin Associated Protein 1 (UBAP1)
Metastasis Associated Protein 1 (MTA1) Polyclonal Antibody (Mouse)
4-PAC630Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Metastasis Associated Protein 1 (MTA1)
Telomerase Associated Protein 1 (TEP1) Polyclonal Antibody (Human)
4-PAA558Hu01
  • EUR 232.00
  • EUR 2285.00
  • EUR 574.00
  • EUR 289.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Telomerase Associated Protein 1 (TEP1)
Contactin Associated Protein 1 (CNTNAP1) Polyclonal Antibody (Human)
4-PAB026Hu01
  • EUR 239.00
  • EUR 2391.00
  • EUR 598.00
  • EUR 299.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Contactin Associated Protein 1 (CNTNAP1)
Contactin Associated Protein 1 (CNTNAP1) Polyclonal Antibody (Mouse)
4-PAB026Mu01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Contactin Associated Protein 1 (CNTNAP1)
Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Human)
4-PAH923Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1)
Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Mouse)
4-PAH923Mu01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1)
Huntingtin Associated Protein 1 (HAP1) Polyclonal Antibody (Rat)
4-PAH923Ra01
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1)
GnRH Associated Peptide (GAP) (1-13), human
A1020-1 1 mg
EUR 90
Description: Sequence: Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-ValThe cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP).
prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]
A1085-1 1 mg
EUR 108
Description: prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens], (C26H41N9O9), a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66.
Pycard ELISA Kit| Mouse Apoptosis-associated speck-like protein
EF016005 96 Tests
EUR 689
Apoptosis Associated Tyrosine Kinase (AATK) Polyclonal Antibody (Human, Mouse, Rat, Pig), APC-Cy7
4-PAA429Hu01-APC-Cy7
  • EUR 526.00
  • EUR 5782.00
  • EUR 1543.00
  • EUR 695.00
  • EUR 299.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse, Rat, Pig Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC-Cy7.
Neuronal Apoptosis Inhibitory Protein (NAIP) Polyclonal Antibody (Human)
4-PAB524Hu01
  • EUR 239.00
  • EUR 2391.00
  • EUR 598.00
  • EUR 299.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Neuronal Apoptosis Inhibitory Protein (NAIP)
Neuronal Apoptosis Inhibitory Protein (NAIP) Polyclonal Antibody (Mouse)
4-PAB524Mu01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Neuronal Apoptosis Inhibitory Protein (NAIP)
Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Apoptosis Associated Tyrosine Kinase ELISA kit
E03A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rabbit Apoptosis Associated Tyrosine Kinase ELISA kit
E04A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Apoptosis Associated Tyrosine Kinase ELISA kit
E02A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Apoptosis Associated Tyrosine Kinase ELISA kit
E06A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human Apoptosis Associated Tyrosine Kinase ELISA kit
E01A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Monkey Apoptosis Associated Tyrosine Kinase ELISA kit
E09A0529-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Apoptosis Associated Tyrosine Kinase ELISA kit
E08A0529-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Apoptosis Associated Tyrosine Kinase ELISA kit
E08A0529-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Apoptosis Associated Tyrosine Kinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

As 3+ or/and Cu 2+ publicity triggers oxidative stress imbalance, induces inflammatory response and apoptosis in rooster mind

 

  • Arsenic (As) and copper (Cu) are frequent environmental pollution in nature. When they’re excessively current in dwelling organisms, they will trigger heavy steel poisoning. There have been comparatively few research of the toxicological concentrations of As and Cu within the mind utilizing rooster as a mannequin. Subsequently, on this research, arsenic trioxide or/and copper sulfate had been added to rooster diets for a 12-week toxicity take a look at.

 

  • The take a look at outcomes confirmed that extreme consumption of As or/and Cu led to a big discount within the complete antioxidant capability (T-AOC), catalase (CAT) and hydroxyl radicals. And important enhance in nitric oxide synthase (NOS) signifies an imbalanced oxidation response. As well as, the rise in warmth shock protein (HSPs), the rise of NF-κB pathway-related pro-inflammatory mediators, the change of apoptosis elements on the loss of life receptor and mitochondrial apoptosis pathway present that, As or/and Cu publicity induced chicken mind has warmth shock response (HSP), tissue irritation and apoptosis.
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-b-48T 48T
EUR 569
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Bcl2 Associated X Protein (Bax) in samples from tissue homogenates, cell lysates or other biological fluids.
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-b-96T 96T
EUR 746
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Bcl2 Associated X Protein (Bax) in samples from tissue homogenates, cell lysates or other biological fluids.
Human Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Hu-48T 48T
EUR 498
Description: A sandwich quantitative ELISA assay kit for detection of Human Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Human Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Hu-96T 96T
EUR 647
Description: A sandwich quantitative ELISA assay kit for detection of Human Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Mu-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Mu-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-p-48T 48T
EUR 569
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-p-96T 96T
EUR 746
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Ra-48T 48T
EUR 528
Description: A sandwich quantitative ELISA assay kit for detection of Rat Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates or other biological fluids.
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
DLR-Bax-Ra-96T 96T
EUR 690
Description: A sandwich quantitative ELISA assay kit for detection of Rat Bcl2 Associated X Protein (Bax) in samples from serum, plasma, tissue homogenates or other biological fluids.
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-b-48Tests 48 Tests
EUR 580
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-b-96Tests 96 Tests
EUR 807
Human Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Hu-48Tests 48 Tests
EUR 500
Human Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Hu-96Tests 96 Tests
EUR 692
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Mu-48Tests 48 Tests
EUR 511
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Mu-96Tests 96 Tests
EUR 709
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-p-48Tests 48 Tests
EUR 580
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-p-96Tests 96 Tests
EUR 807
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Ra-48Tests 48 Tests
EUR 534
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
RD-Bax-Ra-96Tests 96 Tests
EUR 742
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-b-48Tests 48 Tests
EUR 607
Bovine Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-b-96Tests 96 Tests
EUR 845
Human Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Hu-48Tests 48 Tests
EUR 522
Human Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Hu-96Tests 96 Tests
EUR 724
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Mu-48Tests 48 Tests
EUR 534
Mouse Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Mu-96Tests 96 Tests
EUR 742
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-p-48Tests 48 Tests
EUR 607
Porcine Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-p-96Tests 96 Tests
EUR 845
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Ra-48Tests 48 Tests
EUR 558
Rat Bcl2 Associated X Protein (Bax) ELISA Kit
RDR-Bax-Ra-96Tests 96 Tests
EUR 776
Bcl2 Associated X Protein (BAX) Antibody
20-abx125555
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx127101
  • EUR 495.00
  • EUR 356.00
  • 100 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx130706
  • EUR 467.00
  • EUR 133.00
  • EUR 1358.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx130707
  • EUR 300.00
  • EUR 133.00
  • EUR 787.00
  • EUR 411.00
  • EUR 258.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx111032
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx121298
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx000595
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx001820
  • EUR 495.00
  • EUR 704.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx141068
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
Bcl2 Associated X Protein (Bax) Antibody
20-abx132203
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Bcl2 Associated X Protein (Bax) Antibody
20-abx102415
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
abx036006-100ug 100 ug
EUR 391
Bcl2 Associated X Protein (BAX) Antibody
20-abx009554
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx009555
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx013025
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
Bcl2 Associated X Protein (BAX) Antibody
20-abx007345
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx007572
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
Bcl2 Associated X Protein (BAX) Antibody
abx025467-100ul 100 ul
EUR 523
Bcl2 Associated X Protein (BAX) Antibody
abx025468-400ul 400 ul
EUR 523
Bcl2 Associated X Protein (BAX) Antibody
abx025468-80l 80 µl
EUR 286
Bcl2 Associated X Protein (BAX) Antibody
abx030365-400ul 400 ul
EUR 523
Bcl2 Associated X Protein (BAX) Antibody
abx030365-80l 80 µl
EUR 286
Bcl2 Associated X Protein (BAX) Antibody
abx027279-400ul 400 ul
EUR 523
Bcl2 Associated X Protein (BAX) Antibody
abx027279-80l 80 µl
EUR 286
Bcl2 Associated X Protein (BAX) Antibody
20-abx014013
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 119.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 20 ug
  • 300 µg
Bcl2 Associated X Protein (BAX) Antibody
20-abx014014
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
Bcl2 Associated X Protein (Bax) Antibody
20-abx175556
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug
Bcl2 Associated X Protein (Bax) Antibody
20-abx175557
  • EUR 1358.00
  • EUR 648.00
  • 1 mg
  • 200 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx326526
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx328047
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx328414
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
20-abx329399
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
Bcl2 Associated X Protein (BAX) Antibody
abx331454-100ul 100 ul
EUR 425
Bcl2 Associated X Protein (BAX) Antibody
abx332817-100ul 100 ul
EUR 425
Bcl2 Associated X Protein (BAX) Antibody
20-abx241853
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
20-abx242256
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
Bcl2 Associated X Protein (BAX) Antibody
abx230809-100ug 100 ug
EUR 509
Bcl2 Associated X Protein (BAX) Antibody
abx230810-100ug 100 ug
EUR 509
Bcl2 Associated X Protein (BAX) Antibody
abx230811-100ug 100 ug
EUR 509
Bcl2 Associated X Protein (Bax) Antibody
20-abx171398
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
Bcl2 Associated X Protein (Bax) Antibody
20-abx171399
  • EUR 871.00
  • EUR 453.00
  • 1 mg
  • 200 ug
Bcl2 Associated X Protein (Bax) Antibody
20-abx171400
  • EUR 940.00
  • EUR 481.00
  • 1 mg
  • 200 ug
Recombinant Bcl2 Associated X Protein (Bax)
4-RPB343Hu01
  • EUR 456.61
  • EUR 225.00
  • EUR 1437.28
  • EUR 545.76
  • EUR 991.52
  • EUR 368.00
  • EUR 3443.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Bcl2 Associated X Protein expressed in: Prokaryotic expression
Recombinant Bcl2 Associated X Protein (Bax)
4-RPB343Hu02
  • EUR 456.61
  • EUR 225.00
  • EUR 1437.28
  • EUR 545.76
  • EUR 991.52
  • EUR 368.00
  • EUR 3443.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Bcl2 Associated X Protein expressed in: E.coli
Recombinant Bcl2 Associated X Protein (Bax)
4-RPB343Mu01
  • EUR 483.49
  • EUR 232.00
  • EUR 1538.08
  • EUR 579.36
  • EUR 1058.72
  • EUR 386.00
  • EUR 3695.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Bcl2 Associated X Protein expressed in: E.coli
Recombinant Bcl2 Associated X Protein (Bax)
4-RPB343Po01
  • EUR 535.46
  • EUR 246.00
  • EUR 1732.96
  • EUR 644.32
  • EUR 1188.64
  • EUR 421.00
  • EUR 4182.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Bcl2 Associated X Protein expressed in: E.coli
Human Bcl2 Associated X Protein (Bax) Protein
20-abx652157
  • EUR 634.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Pig Bcl2 Associated X Protein (Bax) Protein
20-abx652158
  • EUR 746.00
  • EUR 300.00
  • EUR 2332.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Rat Bcl2 Associated X Protein (Bax) Protein
20-abx652651
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Cow Bcl2 Associated X Protein (Bax) Protein
20-abx652652
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • This injury is inseparable from the oxidative imbalance. It’s value noting that these damage adjustments are time-dependent, and the mixed impact of those two metals is extra extreme than that of a single group of accidents. Our findings can inform the regulation of animal feed components and keep away from agricultural financial losses or organic well being injury.
Key phrases: Apoptosis; Arsenic; Copper; Irritation; Neurotoxicity; Oxidative stress.

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