Foundation of the Istituto Toscano Tumori

ITT Cancer Research – Apoptosis – Oncology

A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis

A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis
Goal: This research aimed to discover the impact of GANT61 on regulating cell proliferation, cell apoptosis and cell cycle, and to research whether or not GANT61 would perform in a number of myeloma (MM) by way of inhibiting Notch pathway.
Strategies: RPMI-8226 and U266 cells had been handled by GANT61 (0, 2.5, 5.0, 10.0, 20.0, 30.0, 40.0, 50.Zero μmol/L) for 18, 24 and 36 hours (h), and cell proliferation was detected by Cell Counting Package 8. Then these cells had been handled by GANT61 at 0, 2.5, 5.0, 10.Zero μmol/L for 24 h or handled by 10.Zero μmol/L GANT61 for 0, 18, 24 and 36 h, and cell apoptosis charge, apoptosis markers and cell cycle had been detected by AV/PI, Western blot, and PI staining. Notch1, Jagged1, Jagged2 and Hes1 expressions had been detected by qPCR and Western blot. Additional rescue experiments had been performed by upregulating Notch1.
Outcomes: In RPMI-8226 and U266 cells, GANT61 inhibited cell proliferation, elevated cell apoptosis charge and cell proportion of G1/G0 part whereas decreased cell proportion of S part in a dose- and time-dependent method. Apart from, GANT61 inhibited Notch1, Jagged1, Jagged2 and Hes1 expressions in a dose- and time-dependent method as effectively. In rescue experiments, Notch1 upregulation attenuated the inhibition of cell proliferation, promotion of cell apoptosis, induction of G1/G0 cycle retardation and repression of Notch signaling pathway induced by GANT61 therapy in RPMI-8226 and U266 cells.
 Conclusions: GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent method by inhibiting Notch pathway in MM.
gentaur
Abbreviations: MM: A number of myeloma; Hh: Hedgehog; EMT: epithelial mesenchymal transition; AML: acute myeloid leukemia; GANT61: GLI antagonist; DMSO: dimethyl sulfoxide; CCK-8: Cell Counting Package 8; C-Caspase 3: Cleaved Caspase 3; Bcl-2: B-cell lymphoma-2; RT-qPCR: real-time quantitative polymerase chain response; OD: optical density; PTCH1: Patched1.
Key phrases: GANT61; A number of myeloma; apoptosis; cell cycle; notch; proliferation.
 
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK)
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC.
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with Cy3.
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with HRP.
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with PE.
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with FITC.
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Description: A Rabbit polyclonal antibody against Mouse Apoptosis Associated Tyrosine Kinase (AATK). This antibody is labeled with APC-Cy7.
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As 3+ or/and Cu 2+ publicity triggers oxidative stress imbalance, induces inflammatory response and apoptosis in rooster mind

 

  • Arsenic (As) and copper (Cu) are frequent environmental pollution in nature. When they’re excessively current in dwelling organisms, they will trigger heavy steel poisoning. There have been comparatively few research of the toxicological concentrations of As and Cu within the mind utilizing rooster as a mannequin. Subsequently, on this research, arsenic trioxide or/and copper sulfate had been added to rooster diets for a 12-week toxicity take a look at.

 

  • The take a look at outcomes confirmed that extreme consumption of As or/and Cu led to a big discount within the complete antioxidant capability (T-AOC), catalase (CAT) and hydroxyl radicals. And important enhance in nitric oxide synthase (NOS) signifies an imbalanced oxidation response. As well as, the rise in warmth shock protein (HSPs), the rise of NF-κB pathway-related pro-inflammatory mediators, the change of apoptosis elements on the loss of life receptor and mitochondrial apoptosis pathway present that, As or/and Cu publicity induced chicken mind has warmth shock response (HSP), tissue irritation and apoptosis.
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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EUR 935
BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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EUR 935
BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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EUR 935
BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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EUR 935
BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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EUR 4050
BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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BAX (Apoptosis Regulator BAX Cytoplasmic Isoform beta, Apoptosis Regulator BAX Membrane isoform alpha, Bax isoform psi, Bax Protein cytoplasmic isoform delta, Bax Protein Cytoplasmic isoform gamma, Bax zeta, Bcl-2-like Protein 4, BCL2 Associated X Protein
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Bax, Recombinant, Mouse (BCL2-associated X protein, Apoptosis regulator BAX)
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Bax, Recombinant, Mouse (BCL2-associated X protein, Apoptosis regulator BAX)
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EUR 1890
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EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4)
MBS6267984-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (AP)
MBS6122087-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (AP)
MBS6122087-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (APC)
MBS6122088-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (APC)
MBS6122088-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (HRP)
MBS6122091-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (HRP)
MBS6122091-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (PE)
MBS6122092-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (PE)
MBS6122092-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (AP)
MBS6265741-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (AP)
MBS6265741-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (HRP)
MBS6266638-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (HRP)
MBS6266638-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (PE)
MBS6266863-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (PE)
MBS6266863-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (APC)
MBS6265966-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (APC)
MBS6265966-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (Biotin)
MBS6122089-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (Biotin)
MBS6122089-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (FITC)
MBS6122090-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (FITC)
MBS6122090-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (Biotin)
MBS6266190-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (Biotin)
MBS6266190-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (FITC)
MBS6266414-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (FITC)
MBS6266414-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 490)
MBS6204287-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 490)
MBS6204287-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 405)
MBS6193612-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 405)
MBS6193612-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 750)
MBS6236312-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 750)
MBS6236312-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 650)
MBS6225637-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 650)
MBS6225637-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 550)
MBS6214962-01mL 0.1(mL
EUR 935
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 550)
MBS6214962-5x01mL 5x0.1mL
EUR 4050
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 550)
MBS6267536-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 550)
MBS6267536-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 650)
MBS6267760-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 650)
MBS6267760-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 405)
MBS6267088-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 405)
MBS6267088-5x01mL 5x0.1mL
EUR 3825
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 490)
MBS6267312-01mL 0.1mL
EUR 885
BAX (BCL2-associated X protein, Apoptosis regulator BAX, BAX protein, BCL2L4, Bcl-2-like Protein 4, Bcl2-L-4) (MaxLight 490)
MBS6267312-5x01mL 5x0.1mL
EUR 3825
Bax (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4)
MBS6507027-01mL 0.1mL
EUR 660
Bax (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4)
MBS6507027-5x01mL 5x0.1mL
EUR 2810
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (AP)
MBS6257848-5x01mL 5x0.1mL
EUR 4765
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (APC)
MBS6258057-01mL 0.1mL
EUR 1090
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (APC)
MBS6258057-5x01mL 5x0.1mL
EUR 4765
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (Biotin)
MBS6258265-01mL 0.1mL
EUR 1090
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (Biotin)
MBS6258265-5x01mL 5x0.1mL
EUR 4765
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (FITC)
MBS6258474-01mL 0.1mL
EUR 1090
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (FITC)
MBS6258474-5x01mL 5x0.1mL
EUR 4765
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (HRP)
MBS6258682-01mL 0.1mL
EUR 1090
BAX (BCL2-associated X protein, Apoptosis regulator BAX, cytoplasmic isoform beta, Apoptosis regulator BAX, membrane isoform alpha, BAX protein, cytoplasmic isoform delta, BAX protein, cytoplasmic isoform gamma, BCL2L4) (HRP)
MBS6258682-5x01mL 5x0.1mL
EUR 4765
  • This injury is inseparable from the oxidative imbalance. It’s value noting that these damage adjustments are time-dependent, and the mixed impact of those two metals is extra extreme than that of a single group of accidents. Our findings can inform the regulation of animal feed components and keep away from agricultural financial losses or organic well being injury.
Key phrases: Apoptosis; Arsenic; Copper; Irritation; Neurotoxicity; Oxidative stress.

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